Endocrine Abstracts

IntroductionOver time, different substances and protocols have been used and tested for stimulating calcitonin (CT). Some of them proved to be useful in diagnosing medullary thyroid carcinoma (MTC). However, these are associated with side-effects, with various duration, intensity and severity.ObjectiveTo report the side-effects observed during CT stimulation test with calcium (Ca) gluconate.<p class="abst...

IntroductionAnti-thyroid drugs (ATDs) are the first line treatment in Europe for hyperthyroidism due to Graves’ disease (GD). Adding levothyroxine to ATDs, so called block and replace therapy (BRT) is still controversial.AimTo follow up the outcomes after treating patients with Graves’ disease in a block and replace regimen.Patients & methodsA prospe...

New possible pathogenic variants involved in pheochromocytomas and paragangliomasIntroduction: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the chromaffin tissues that store and release catecholamines in excess. Most pheochromocytomas are sporadic, usually resulting in unilateral adrenal tumor, but 25–45% harbour a germline mutation.Aim: To describe new possible pathogenic variants (VUS) involved in PPGLs.</...

Introduction: Adrenal hyperplasia is found in more than 15% of abdominal imaging procedures in adults, unrelated to endocrine disorders, especially after the COVID era. Adrenal management is consequently recommended.Aim: To retrospectively evaluate the adrenal status in terms of morphological progression and functional impairment of adrenal function, in a cohort of cases admitted at least yearly in the National Institute of Endocrinology, Bucharest, Roma...

Introduction: Assessment of adrenal insufficiency (AI) is done routinely through Synacthen test. However, the conventional high dose (250 μg) stimulation is supra-physiological, therefore 1 μg low dose test was developed.Aim: to investigate the utility of the Low-dose test vs the High-dose test, in patients with suspected central AI, in a tertiary centre of endocrinology, in the National Institute of Endocrinology, Bucharest, Romania.<p cla...

Introduction: Pheochromocytoma is a rare tumor, representing a cause of secondary endocrine hypertension. Traditionally, prior to the widespread availability of imaging investigations, pheochromocytoma was diagnosed based on the triad: headache, palpitations and sweating. Diagnosis is crucial, as 40-50% of pheochromocytoma patients exhibit genetic mutations associated with multiple syndromes, such as MEN2 syndrome, succinate dehydrogenase enzyme mutations, neurofibromatosis ty...

Context: Graves’ ophthalmopathy (GO) is a debilitating condition that affects 30% patients with Graves’ disease (GD). It is the most common extra-thyroidal manifestation of GD, but only 3-5% of GO cases are sight – threatening.Objective: To compare the thyroid and lipid profile of GD patients who developed GO vs those without GO. The second objective is to analyze the prevalence of smoking status and insufficient 25 (OH) vitamin D levels.<...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

The relationship between the level of genetic variation in CYP17, PSA genes and prostate cancer has been extensively studied but the results are still unclear. A 450c17a (CYP17) polymorphism A1/A2 was described to be significantly associated to prostate cancer. A SNP in the promotor PSA gene is an A to G substitution at position −158 (G158A) was proposed to interact differently with AR, thereby modifying the expression pattern and occurrence of prostate cancer.<p cla...